L-citrulline is an amino acid that may play a role in testosterone production. Here's an overview of the research on L-citrulline and testosterone:
- L-citrulline is converted into L-arginine in the kidneys. L-arginine is a precursor for nitric oxide, which helps dilate blood vessels and improve blood flow. Better circulation to tissues like the testes may support healthy testosterone.
- Small studies in men have found that taking L-citrulline supplements increases levels of L-arginine, nitric oxide metabolites, and growth hormone - all of which may support testosterone. However, these studies did not measure testosterone directly.
- An 8-week study in 41 middle-aged men with mild erectile dysfunction found that taking 1.5 grams of L-citrulline per day significantly increased testosterone levels compared to placebo.
- Other research shows supplemental L-citrulline boosts nitric oxide and exercise performance. This may help support testosterone indirectly via effects on muscle growth, body composition, and workout recovery.
- One potential way L-citrulline may increase testosterone is by reducing arginase activity. Arginase is an enzyme that breaks down L-arginine. By limiting arginase, more L-arginine may be available for nitric oxide production and other molecular pathways involved in testosterone synthesis.
So in summary, current research indicates that
L-citrulline supplementation can increase testosterone levels, especially in middle-aged or older men. Potential mechanisms include:
- Increasing nitric oxide production and blood flow
- Providing more L-arginine substrate for nitric oxide synthesis
- Improving growth hormone levels
- Enhancing exercise performance and muscle growth
- Inhibiting arginase activity and making more L-arginine available
The optimal supplemental dose of
L-citrulline for raising
testosterone is not firmly established, but research has used doses ranging from 1,000 - 3,000 mg per day. Since L-citrulline is considered very safe with few side effects, experimenting within this dosage range under medical supervision seems reasonable.
Of course,
L-citrulline is not a magic bullet for fixing low
testosterone. A number of lifestyle factors like diet, exercise, sleep, and stress management also play a major role. But when used alongside these healthy habits, L-citrulline supplementation appears useful for giving
testosterone levels an extra nudge higher - especially for men over 40.
If you're dealing with symptoms of low
testosterone and want to try increasing levels naturally before considering prescription testosterone replacement, consider giving an
L-citrulline supplement a shot.
Balanced Hormone Clinic offers high-quality L-citrulline capsules, personal hormone testing, and customized treatment plans to help address low
testosterone. Contact us today for more information or to schedule a consultation with one of our hormone health experts.
